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BraIn Plasticity & behavior changes



Research objectives




Our expertise consists in the acquisition and analysis of fMRI, TMS and EEG data from healthy participants and neurological or psychiatric patients.


The aim is the quantification of brain clusters involved in specific psychological functions and to develop measurement tools to detect behavioural and brain changes following training, comparing pre- and post-treatment brain patterns.

Neuroimaging studies of neuroaesthetics, video games and attentional modulation.

Sarasso, P., Ninghetto, M., Salatino, A., Ronga, I., Bongiardina, A., Iarrobino, I., Neppi-Modona, M., Ricci R. (2019). Everything is (still) illuminated: dual right cathodal-left anodal tDCS of PPC prevents fatigue on a visual detection task. Brain Stimulation: Basic, Translational, and Clinical Research in Neuromodulation. doi: 10.1016/j.brs.2018.09.017


Amadeo, M.B., Schinello, M., Caglio, M., Geminiani, G.C., Sacco, K. (2018) Navigational training in virtual environments: A pilot fMRI study on healthy participants. Sistemi Intelligenti, 30 (1), pp. 107-122.


Palermo, S., Lopiano, L., Morese, R., Zibetti, M., Romagnolo, A., Stanziano, M., Rizzone, M.G., Geminiani, G.C., Valentini, M.C., Amanzio, M. (2018). Role of the cingulate cortex in dyskinesias-reduced-self-awareness: An fMRI study on Parkinson's disease patient. Frontiers in Psychology, 9 (SEP), art. no. 1765.


Ricci, R., Ghiggia, A., La Rosa, I., Milano, A., Troni, W., George, M. S., Borckardt, J.J., Castelli, L., Salatino, A. (2018). Anodal Transcranial Direct Current Stimulation of the motor cortex reduces chronic pain in Alcock canal syndrome. Brain Stimulation: Basic, Translational, and Clinical Research in Neuromodulation. 11(3), 648-650


Dimitri, D., De Filippis, D., Galetto, V., Zettin, M.  (2017). Evaluation of the effectiveness of transcranial direct current stimulation (tDCS) and psychosensory stimulation through DOCS scale in a minimally conscious subject. Neurocase, 23 (2), pp. 96-104


Gabbatore, I., Bosco, F.M., Geda, E., Gastaldo, L., Duca, S., Costa, T., Bara, B.G., Sacco, K. (2017). Cognitive Pragmatic rehabilitation program In schizophrenia: A single case fMRI study. Neural Plasticity, art. no. 1612078


Diano, M., D’Agata, F., Cauda, F., Costa, T., Geda, E., Sacco, K., Duca, S., Torta, D.M., Geminiani, G.C. (2016). Cerebellar Clustering and Functional Connectivity During Pain Processing. Cerebellum, 15 (3), pp. 343-356.


Sacco, K., Galetto, V., Dimitri, D., Geda, E., Perotti, F., Zettin, M., Geminiani, G.C. (2016). Concomitant use of transcranial direct current stimulation and computer-assisted training for the rehabilitation of attention in traumatic brain injured patients: Behavioral and neuroimaging results. Frontiers in Behavioral Neuroscience, 10 (MAR), art. no. 57,


Cauda, F., Costa, T., Diano, M., Sacco, K., Duca, S., Geminiani, G., Torta,  (2014). D.M.E. Massive modulation of brain areas after mechanical pain stimulation: A time-resolved fMRI study. Cerebral Cortex, 24 (11), pp. 2991-3005.


Salatino, A., Berra, E., Troni, W., Sacco, K., Cauda, F., D'Agata, F., Geminiani, G., Duca, S., Dimanico, U., Ricci, R. (2014). Behavioral and neuroplastic effects of low-frequency rTMS of the unaffected hemisphere in a chronic stroke patient: A concomitant TMS and fMRI study. Neurocase, 20 (6), pp. 615-626.  


Cauda, F., Torta, D.M.E., Sacco, K., D'Agata, F., Geda, E., Duca, S., Geminiani, G., Vercelli, A. (2013). Functional anatomy of cortical areas characterized by von Economo neurons. Brain Structure and Function, 218 (1), pp. 1-20.


Torta, D.M., Diano, M., Costa, T., Gallace, A., Duca, S., Geminiani, G.C., Cauda, F. (2013). Crossing the line of pain: FMRI correlates of crossed-hands analgesia. Journal of Pain, 14 (9), pp. 957-965.


D'Agata, F., Costa, T., Caroppo, P., Baudino, B., Cauda, F., Manfredi, M., Geminiani, G., Mortara, P., Pinessi, L., Castellano, G., Bisi, G. (2013). Multivariate analysis of brain metabolism reveals chemotherapy effects on prefrontal cerebellar system when related to dorsal attention network.  EJNMMI Research, 3 (1), art. no. 22, pp. 1-9.


Ronga, I., Valentini, E., Mouraux, A., Iannetti, G.D. (2013) “Novelty is not enough: laser-evoked potentials are determined by stimulus saliency, not absolute novelty”. Journal of Neurophysiology, 109: 692-701.


Sikandar, S., Ronga, I., Iannetti, G.D., Dickenson, A. H. (2013). Neural coding of nociceptive stimuli - from rat spinal neurones to human perception. Pain, 154(8): 1263-73.


Baudino, B., D'Agata, F., Caroppo, P., Castellano, G., Cauda, S., Manfredi, M., Geda, E., Castelli, L., Mortara, P., Orsi, L., Cauda, F., Sacco, K., Ardito, R.B., Pinessi, L., Geminiani, G., Torta, R., Bisi, G.  (2012). The chemotherapy long-term effect on cognitive functions and brain metabolism in lymphoma patients. Quarterly Journal of Nuclear Medicine and Molecular Imaging, 56 (6), pp. 559-568.


Cauda, F., Costa, T., Torta, D.M.E., Sacco, K., D'Agata, F., Duca, S., Geminiani, G., Fox, P.T., Vercelli, A. (2012). Meta-analytic clustering of the insular cortex. Characterizing the meta-analytic connectivity of the insula when involved in active tasks. NeuroImage, 62 (1), pp. 343-355.


Legrain, V., Mancini, F., Sambo, C. F., Torta, D. M., Ronga, I., Valentini E. (2012) Cognitive aspects of nociception and pain. Bridging neurophysiology and neuropsychology. Neurophysiologie Clinique/Clinical Neurophysiology, Special Issue L. Plaghki & A. Mouraux (eds.), 42: 325-336 (Invited rewiev).


Torta, D.M.E., Vizzari, V., Castelli, L., Zibetti, M., Lanotte, M., Lopiano, L., Geminiani, G. (2012). Impulsivities and Parkinson's Disease: Delay Aversion Is Not Worsened by Deep Brain Stimulation of the Subthalamic Nucleus. PLoS ONE, 7 (9), art. no. e43261.


Amanzio, M., Torta, D.M.E., Sacco, K., Cauda, F., D'Agata, F., Duca, S., Leotta, D., Palermo, S., Geminiani, G.C. (2011). Unawareness of deficits in Alzheimer's disease: Role of the cingulate cortex. Brain, 134 (4), pp. 1061-1076.


Cauda, F., Cavanna, A.E., D'agata, F., Sacco, K., Duca, S., Geminiani, G.C.  (2011). Functional connectivity and coactivation of the nucleus accumbens: A combined functional connectivity and structure-based meta-analysis. Journal of Cognitive Neuroscience, 23 (10), pp. 2864-2877.


Cauda, F., D'Agata, F., Sacco, K., Duca, S., Geminiani, G., Vercelli, A. (2011). Functional connectivity of the insula in the resting brain. NeuroImage, 55 (1), pp. 8-23.


Cauda, F., Geda, E., Sacco, K., D'Agata, F., Duca, S., Geminiani, G., Keller, R. (2011). Grey matter abnormality in autism spectrum disorder: An activation likelihood estimation meta-analysis study. Journal of Neurology, Neurosurgery and Psychiatry, 82 (12), pp. 1304-1313.


Cauda, F., D'Agata, F., Sacco, K., Duca, S., Cocito, D., Paolasso, I., Isoardo, G., Geminiani, G. (2010). Altered resting state attentional networks in diabetic neuropathic pain. Journal of Neurology, Neurosurgery and Psychiatry, 81 (7), pp. 806-811.


Cauda, F., Geminiani, G., D'Agata, F., Sacco, K., Duca, S., Bagshaw, A.P., Cavanna, A.E. (2010). Functional connectivity of the posteromedial cortex PLoS ONE, 5 (9), art. no. e13107, pp. 1-11


Spena, G., Nava, A., Cassini, F., Pepoli, A., Bruno, M., D'Agata, F., Cauda, F., Sacco, K., Duca, S., Barletta, L., Versari, P. (2010). Preoperative and intraoperative brain mapping for the resection of eloquent-area tumors. A prospective analysis of methodology, correlation, and usefulness based on clinical outcomes. Acta Neurochirurgica, 152 (11), pp. 1835-1845.


Cauda, F., Micon, B.M., Sacco, K., Duca, S., D'agata, F., Geminiani, G., Canavero, S. Disrupted intrinsic functional connectivity in the vegetative state (2009) Journal of Neurology, Neurosurgery and Psychiatry, 80 (4), pp. 429-431.


Cauda, F., Sacco, K., D'Agata, F., Duca, S., Cocito, D., Geminiani, G., Migliorati, F., Isoardo, G. (2009). Low-frequency BOLD fluctuations demonstrate altered thalamocortical connectivity in diabetic neuropathic pain. BMC Neuroscience, 10, art. no. 138, .


Cauda, F., Sacco, K., Duca, S., Cocito, D., D'Agata, F., Geminiani, G.C., Canavero, S. (2009). Altered resting state in diabetic neuropathic pain. PLoS ONE, 4 (2), art. no. e4542, .


Duca, S., Vittorini, R., Pleri, I., Sacco, K., Cauda, F., Capizzi, G. (2004). Visual fMRI in the syndrome occipital calcifications, coeliac disease, epilepsy: Preliminary results. Bollettino - Lega Italiana contro l'Epilessia, (125-126), pp. 381-383.


Perozzo, P., Lopiano, L., Rizzone, M., Marson, A.M., Lanotte, M., Geminiani, G., Bergamasco, B.  (1999). Deep brain stimulation of subthalamic nucleus: Neuropsychological follow-up. Italian Journal of Neurological Sciences, 20 (4), p. 280.


Geminiani, G., Bottini, G., Sterzi, R. (1998). Dopaminergic stimulation in unilateral neglect. Journal of Neurology Neurosurgery and Psychiatry, 65 (3), pp. 344-347.


Broggi, G., Brock, S., Franzini, A., Geminiani, G. (1993). A case of posttraumatic tremor treated by chronic stimulation of the thalamus. Movement Disorders, 8 (2), pp. 206-208.

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